Sat. May 25th, 2019

New Proteins Progressing DKD to ERSF

Joslin Diabetes Center

Diabetes is a very common disease between humans that affects the concentration of glucose in the body. It can be handled and controlled at a certain point but after further complications, it can no longer be treated and may lead to severe dangerous complications. It is important to be able to treat it and locate it at an early stage before further complications.

A very rare form of diabetes is Diabetic Kidney Disease (DKD) which is hard to handle and treat. However, a certain pattern was observed that included people having DKD to move forward in complications reaching end-stage renal disease (ERSD); which is kidney failure.

A recent study conducted by a team of researchers at the Joslin Diabetes Center was able to find a protein in the body that connected the progression from DKD to ESRD. The results were shocking and were published in the Nature Medicine Journal. The study included the use of 219 patients with type 1 diabetes and 144 patients with type 2 diabetes.

Accordingly, they set a total of 17 proteins in the body that are circulating inflammatory proteins named Kidney Risk Inflammatory Signature. The study was led by PhD holder Andrzej Krolewski who is the Andrzej Krolewski. He commented on the obtained results saying, “The finding is amazing. It looks like inflammatory processes the underlie progression to end stage renal disease are similar across two diabetes types and differing race backgrounds. The disease process is very homogenous.”