Sclerosis (also known as sclerosis) is an uncommon chronic ailment characterised by excessive collagen formation and build-up in the body's tissues. Scleroderma can harm numerous major internal organs, including the kidney, lungs, heart, and other essential organs, despite the fact that it predominantly affects the skin. Systemic scleroderma is a chronic inflammatory disease that causes tissue thickening in both the skin and the body's organs. Skin patches contract and thicken as a result of systemic scleroderma, making it difficult to move around in the affected area. Depending on the severity of the systemic scleroderma illness, the quantity and size of patches may vary. Raynaud's disease, which causes discomfort and numbness in the fingers and toes in response to severely cold temperatures, is one of the first indications of systemic scleroderma. Intestinal damage caused by chronic systemic scleroderma can manifest as cramps, diarrhoea, constipation, heartburn, and a difficulty to absorb nutrients into the body's tissues. If systemic scleroderma is not treated in a timely manner, it can be fatal. In the future years, the systemic scleroderma treatment market is projected to be driven by additional approvals for existing treatment alternatives, as well as the introduction of first-in-class medications that are currently in development.
Off-label usage of medications approved for symptomatic indications including rheumatoid arthritis is driving the systemic scleroderma treatment market. Due to a scarcity of curative drugs and a high likelihood of off-label prescription use, investing in uncommon illness markets is becoming increasingly popular. As a result, a targeted biologic and small molecule combination treatment will almost certainly be created.
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Influence of a Pandemic – Global Systemic Scleroderma Treatment Market
The World Health Organization (WHO) declared a global pandemic of SARS-CoV-2 infection after it was discovered in Wuhan, China, in December 2019, characterising it as a novel Coronavirus. SARS-CoV-2 infection was first found in December 2019 in Wuhan, China. (COVID-19). COVID-19 has spread over the world, infecting more than 211 million people and causing more than 4.4 million deaths as of August 22, 2021, according to the World Health Organization's Coronavirus (COVID-19) Weekly Epidemiological Update. COVID-19 has wreaked havoc on the healthcare business, causing widespread supply chain disruptions covering the whole supply chain, from raw materials to manufacturing and delivery. COVID-19 has been linked to systemic scleroderma in a recent study, which is expected to boost the total growth of the systemic scleroderma treatment market throughout the pandemic period.
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Global systemic scleroderma treatment market report's main findings are as follows:
Immunosuppressors accounted for more than 60% of global systemic scleroderma treatment market revenue in 2021, and are likely to maintain their dominance in the systemic scleroderma therapy business over the forecast period because of their increasing efficiency and dramatically improved results.
Systemic scleroderma therapy will continue to dominate the global systemic scleroderma treatment market during the forecast period, accounting for over 40% of the total market during the forecast period. A strong pharmaceutical pipeline, in addition to favourable reimbursement conditions, is supporting in the expansion of the systemic scleroderma treatment market.
According to industry estimations, companies including Roche Ltd., United Therapeutics, and Boehringer Ingelheim International GmbH have registered for a considerable market share in 2021 in the global systemic scleroderma treatment market. In September 2019, the U.S. Food and Drug Administration approved Ofev (nintedanib), a drug developed by Boehringer Ingelheim International GmbH, for the treatment of individuals suffering from Systemic Sclerosis with Interstitial Lung Disease (SSc-ILD). In April 2020, the European Medicines Agency authorised the medication. Similarly, in June 2020 Pfizer Inc. announced that phase 3 clinical trials for Revatio, a drug used to treat pulmonary hypertension in infants had been completed. ERAs have remained in the public eye as a result of their use in the treatment of a high-incidence indication like PAH.
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Key Companies in the Global Systemic Scleroderma Treatment Market are listed Below:
- Amgen Inc.
- Argentis Pharmaceuticals, LLC
- Bayer AG
- Biogen
- Boehringer Ingelheim International GmbH
- Bristol-Myers Squibb Company
- Celgene Corporation
- Corbus Pharmaceuticals Holdings, Inc
- Eli Lilly and Company
- GlaxoSmithKline plc
- Hoffmann La Roche Ltd.
- Johnson & Johnson Services, Inc.
- Mylan N.V.
- Novartis AG
- Ono pharmaceutical co. Ltd.
- Pfizer Inc.
- Sanofi
- Teva Pharmaceutical Industries Ltd.
- United Therapeutics
- Other Market Participants
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Global Systemic Scleroderma Treatment Market
By Drug Class
- Immunosuppressant
- Phosphodiesterase 5 Inhibitors (PHA)
- Endothelin Receptor Antagonists
- Prostacyclin Analogues
- Calcium Channel Blockers
- Others
By Distribution Channel
- Offline
- Online
By Disease Type
- Limited Systemic Sclerosis
- Diffused Systemic Sclerosis
- Systemic Sclerosis Sine Scleroderma
By Route of Administration
- Oral
- Parenteral
By Region
- North America (U.S., Canada, Mexico, Rest of North America)
- Europe (France, The UK, Spain, Germany, Italy, Nordic Countries (Denmark, Finland, Iceland, Sweden, Norway), Benelux Union (Belgium, The Netherlands, Luxembourg), Rest of Europe
- Asia Pacific (China, Japan, India, New Zealand, Australia, South Korea, Southeast Asia (Indonesia, Thailand, Malaysia, Singapore, Rest of Southeast Asia), Rest of Asia Pacific
- Middle East & Africa (Saudi Arabia, UAE, Egypt, Kuwait, South Africa, Rest of Middle East & Africa)
- Latin America (Brazil, Argentina, Rest of Latin America)
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