An inherited illness called cystic fibrosis causes the lungs and digestive tract to become clogged with thick, sticky mucus. From an early age, it can lead to breathing and gastrointestinal issues. The lungs sustain progressive damage over many years and may eventually stop functioning properly. Every racial and ethnic group can be impacted by cystic fibrosis, which affects up to 40,000 children and adults in the United States and an estimated 105,000 people worldwide who have received a diagnosis. Over the years iterative cycles of therapeutic development have resulted in the advancement of numerous treatments for cystic fibrosis symptoms and clinical management techniques, changing the disease's reputation from a fatal childhood illness to one with over 50% of patients in the United States becoming adults. The expense of caring for CF patients is considerable as a result of therapeutic advancements, and most patients still pass away from respiratory failure despite progress. A potential strategy needs to be developed to address the fundamental flaw in cystic fibrosis with systemic small drugs. The clinical development of investigational medications that restore function to faulty CFTR protein in multiple tissues in CF patients has been made possible by a fruitful partnership between a non-profit health organization and a pharmaceutical business, supported by academic researchers and patients.
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Global Cystic Fibrosis Therapeutics Market Share in 2021, By Region
Furthermore, with recent advancements the outlook for patients who have the exact mutations targeted by the drug therapies has been significantly improved because a new class of medications meant to address genetic flaws that cause cystic fibrosis (CF). Leading players in the cystic fibrosis therapeutics market are introducing advanced therapies for the treatment of cystic fibrosis. For instance, although cystic fibrosis gene therapy is not currently feasible, significant progress is being made in finding cures for the CF gene defect. Scientists have successfully grown cells from CF sufferers' nasal passages in lab settings. The faulty chloride transport in these cells was fixed by the researchers by introducing the healthy gene. Therefore, it is projected that the global cystic fibrosis therapeutics market will gain tremendous momentum in the near future.
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Global Cystic Fibrosis Therapeutics Market Report :
There are various types of test for the diagnosis of cystic fibrosis which are sweat test, genetic tests, DNA test, newborn screening, chest X-ray and others. The sweat test had the highest share under the test type segment in 2021, as it is commonly used for the diagnosis of cystic fibrosis wherein it measures the amount of chloride in sweat. Chloride is part of the salt that is found in sweat. Because individuals with cystic fibrosis (CF) have greater levels of chloride in their sweat, the test can identify cystic fibrosis. On the other hand, immunoreactive trypsinogen (IRT) test is a standard newborn screening test that checks the blood for abnormal levels of the protein called IRT. A high level of IRT may be a sign of cystic fibrosis. However, further testing is required to confirm the diagnosis and thus various tests are carried out for cystic fibrosis therapeutics.
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Antibiotics and anti-inflammatory drugs have had the highest share in the drug class segment. The anti-inflammatory therapies that have been tested the most so far include oral corticosteroids, which are effective but have considerable long-term adverse effects, and inhaled corticosteroids, which have not yet shown to be helpful, likely due to absorption issues. Furthermore, bronchodilators have been used for years in the treatment of airway obstruction associated with cystic fibrosis. Their effectiveness in bringing about consistent and significant reversal of airway obstruction remains skeptical. Hence, there have been transformative changes in cystic fibrosis treatment in the past 10 years. The introduction of cystic fibrosis transmembrane regulator (CFTR) modulators revolutionized therapy for many people with cystic fibrosis.
North America had the highest share in the cystic fibrosis therapeutics market in the year 2021. Cystic fibrosis is a growing concern in United States as there are close to 40,000 children and adults living with cystic fibrosis in the United States and an estimated 105,000 people have been diagnosed with cystic fibrosis across 94 countries and can affect people of every racial and ethnic group. In the last few years with rising concerns, healthcare organizations and government bodies are investing into advanced therapeutics for cystic fibrosis. Moreover, leading players in the cystic fibrosis therapeutics market are heavily investing into advanced research and development of cystic fibrosis therapeutics wherein the companies are collaborating to launch new treatments and drugs for cystic fibrosis. Thus, in the upcoming years the cystic fibrosis therapeutics market is expected to upsurge during the forecast period.
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Some of the companies operating in the global cystic fibrosis therapeutics market are:
- AbbVie Inc.
- Alcresta Therapeutics, Inc
- CHIESI Farmaceutici S.p.A
- Genentech, Inc.
- Gilead Sciences, Inc.
- Horizon Therapeutics plc
- Laurent Pharmaceuticals Inc
- Mylan N.V.
- Novartis AG
- Pharmaxis Ltd
- Teva UK Limited
- Vertex Pharmaceuticals Incorporated
- Other Market Participants
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Global Cystic Fibrosis Therapeutics Market:
- Sweat test
- Genetic test
- DNA test
- Newborn Screening
- Chest X-ray
- Anti-inflammatory drugs
- CFTR modulators
- Mucus thinning medications
- Nasal and sinus surgery
- Bowel Surgery
- Liver transplant
- Lung transplant
By Route Of Administration
By Age Group
- North America (U.S., Canada, Mexico, Rest of North America)
- Europe (France, The UK, Spain, Germany, Italy, Nordic Countries (Denmark, Finland, Iceland, Sweden, Norway), Benelux Union (Belgium, The Netherlands, Luxembourg), Rest of Europe
- Asia Pacific (China, Japan, India, New Zealand, Australia, South Korea, Southeast Asia (Indonesia, Thailand, Malaysia, Singapore, Rest of Southeast Asia), Rest of Asia Pacific
- Middle East & Africa (Saudi Arabia, UAE, Egypt, Kuwait, South Africa, Rest of Middle East & Africa)
- Latin America (Brazil, Argentina, Rest of Latin America)
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