Optogenetics is a field that combines optics and genetic engineering to assess and regulate cells (usually neurons) and the biomolecular mechanisms that govern them. Neuroscientists use light to manipulate neurons with great spatial and temporal resolution using optogenetics, a research tool. Light-sensitive proteins are expressed in specific brain neurons that have been genetically engineered. The proteins in these neurons are triggered when light strikes them, causing the neuron to fire. Neuroscientists are using optogenetics to evaluate the impact of turning a group of neurons on or off in real time. Since 2004 through 2009, optogenetics was being developed. Several laboratories throughout the world began adopting optogenetics as a result, and thousands of scientific findings mostly in neurology but sometimes in other fields have been published using this technology. Optogenetics' biomedical applications emerged from the necessity to precisely and quickly regulate individual cells in a vertebrate brain in order to unravel the neuronal circuitries driving behavior and disease, replacing techniques that were not precise enough to target specific neuron populations.
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Optogenetics is proving to be an alternative treatment for various chronic diseases as well. Since optogenetics can be used to turn neurons on and off, it has a lot of potential as a treatment for chronic pain. Specific pain signals can be suppressed by selectively turning off pain-sensing neurons, resulting in the absence of pain sensations. Moreover, the leading players in the market are investing into clinical trials for effective results and to widen the scope for applications. For instance, RetroSense Therapeutics, a startup based in Ann Arbor, Michigan, begun the first clinical trial of an optogenetics-based therapy in humans. Optogenetic medicines based on this breakthrough technology will begin to appear in the clinic when technological challenges blocking its application in humans are solved and optogenetic techniques progress to have more control over neurons. Optogenetics' introduction as a research tool has aided the launch of large-scale, national-scale brain-research initiatives, such as the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, which began in the United States in 2013. Thus, with such initiatives and advancements the global optogenetics market is anticipated to upsurge during the forecast period.
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Segmental Insights - Global Optogenetics Market
Optogenetic approaches have been used to investigate a wide range of topics in behaviour and physiology, including behavioral tracking. Clinically relevant discoveries have also been produced, shedding light on cellular activity linked to epilepsy, Parkinson's disease, Huntington's disease, stroke, chronic pain, and other disorders. Optogenetics, for example, made it feasible to figure out which brain cells and connections were crucial in defining and assembling the various characteristics of anxiety, such as respiratory rate alterations and risk avoidance, into a discrete behavioral state. Furthermore, optogenetics is rapidly growing science that aims to restore vision function in disorders that cause blindness, such as retinitis pigmentosa (RP). Through inserting light-sensitive proteins into downstream retinal neurons that have no innate light sensitivity, optogenetic techniques to vision restoration aim to replace destroyed or defective photoreceptors. Such techniques are appealing since they are unaffected by the genetic causes of retinal degeneration, raising optimism that all forms of retinal dystrophic and degenerative illnesses will be treated in the future. Thus, with advancements in optogenetics various disorders will be cured leading to the growth of optogenetics market globally.
Although optogenetics is a relatively new technology, multiple therapeutic options are already being explored in pre-clinical and phase I/II clinical trials. The major players in the healthcare industry are acquiring optogenetics companies and startups. For instance, Novartis has acquired Arctos Medical, expanding its ophthalmology portfolio with a pre-clinical optogenetics-based AAV gene therapy product and Arctos' patented technology and strengthen their ophthalmology treatment offerings. Thus, the rising awareness about optogenetics and its advantages, the global optogenetics market is expected to upsurge in the upcoming years.
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Regional Analysis - Global Optogenetics Market
Asia Pacific region is anticipated to be the fastest growing region in the optogenetics market for the forecast period 2022-2030. Healthcare organization and government bodies in Asia pacific region are looking forward in investing into optogenetics for various treatments. Moreover, clinical trials of optogenetics for human diseases has led to a huge demand in countries like India, Japan, Australia and others. New developments in optogenetics, such as wireless microchips, have made it possible to treat conditions like depression and Parkinson's disease more conveniently which has led to a huge growth of optogenetics market in the Asia Pacific region.
Competitors - Global Optogenetics Market
- Campden Instruments
- Coherent, Inc
- Elliot Scientific Ltd.
- Gensight Biologics
- Judges Scientific plc
- Merck KGaA
- Nanoscope Therapeutics, Inc.
- Noldus Information Technology
- Thorlabs, Inc.
- Other Industry Participants
Global Optogenetics Market:
By Product Type
- Behavioural Tracking
- Retinal Disease Treatment
By End Users
- Hospitals and Clinics
- Diagnostics Centers
- Research Centers
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- North America (U.S., Canada, Mexico, Rest of North America)
- Europe (France, The UK, Spain, Germany, Italy, Nordic Countries (Denmark, Finland, Iceland, Sweden, Norway), Benelux Union (Belgium, The Netherlands, Luxembourg), Rest of Europe
- Asia Pacific (China, Japan, India, New Zealand, Australia, South Korea, Southeast Asia (Indonesia, Thailand, Malaysia, Singapore, Rest of Southeast Asia), Rest of Asia Pacific
- Middle East & Africa (Saudi Arabia, UAE, Egypt, Kuwait, South Africa, Rest of Middle East & Africa)
- Latin America (Brazil, Argentina, Rest of Latin America)
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